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Not all "pancreatic cancer" is pancreatic cancer——The Journal of the American Medical Association (JAMA) published the comments of Professor Yi Miao from the Pancreas Center



Published on:2022-04-13   Views:2617
Pancreatic cancer is one of the malignant tumors with the worst prognosis in humans. In the past three decades, although the overall five-year survival rate of pancreatic cancer has almost doubled, it is still only about 10%, making it the strongest fortress on the battlefield between humans and tumors. In this "battlefield", the world's top basic scientific researchers, epidemiologists, surgeons, oncologists, and experts and scholars from various fields such as imaging and pathology have gathered in their respective work for pancreatic cancer. Cancer patients fight for hope of survival and a cure.
In October 2021, an epidemiological study on pancreatic cancer published in the "Journal of the American Medical Association" attracted the attention and interest of Professor Miao Yi from the Pancreatic Center of Jiangsu Provincial People's Hospital (The First Affiliated Hospital of Nanjing Medical University). A study from Cedars-Sinai Medical Center in Los Angeles, USA showed that the incidence of pancreatic cancer in the United States increased in the nearly two decades from 2000 to 2018; among young and middle-aged people (<55 years old), pancreatic cancer in women The incidence is significantly higher than that of men; among young (<35 years old) women, the average annual increase in pancreatic cancer incidence is even as high as 7.68%. In the past medical literature, monograph reports and the clinical experience of surgeons, men with pancreatic cancer tend to be more common than women. Professor Miao Yi was keenly aware that there must be objective reasons to be revealed behind this pair of seemingly contradictory conclusions, so he organized a team to conduct a literature review, and at the same time applied for the epidemiological data permission of the above research and conducted data mining, and finally found the possible scientific explanation.
"Not all 'pancreatic cancers' are pancreatic cancers in the eyes of doctors," explained Prof. Yi Miao. "In clinical practice, pancreatic cancers are generally referred to as pancreatic ductal adenocarcinoma (PDAC). Cases labeled 'pancreatic cancer' in the U.S. epidemiological database are more accurately called 'pancreatic malignancies'; these include solid-pseudopapillary tumors of the pancreas, which are significantly more common in women, and With the improvement of social health and social status of women, more and more women with this type of tumor can be diagnosed and treated at a young age, which may lead to a high incidence and growth rate of pancreatic cancer in young and middle-aged women. In men. Although recurrence and metastasis are also possible, the biological behavior and therapeutic effects of these tumors are far superior to true pancreatic cancer.”
In addition, the results based on the relevant databases of the World Health Organization show that young and middle-aged women in some Western European countries such as the United Kingdom, Germany, and the Netherlands are also more likely to develop pancreatic cancer than men of the same age. This trend is in mainland China and Hong Kong in Asia. However, it is reversed, which seems to imply the influence of anthropological genetic background and social development level on the incidence of pancreatic cancer in young and middle-aged people.

Director Jiang Kuirong of the Pancreas Center said: "Journal of the American Medical Association, also known as JAMA in the mouth of medical workers, has a history of nearly 120 years and is one of the four major international medical journals. We are the first affiliate of Nanjing Medical University. The Pancreatic Center of the hospital maintains an annual volume of more than 1,000 pancreatic surgeries, has established the largest high-quality pancreatic biological sample bank in East Asia, and participated in a number of international multi-center clinical studies. The recognition and positive feedback from many scholars including the author and editor. We believe that this confirms Professor Miao's solid professional knowledge, keen insight and rigorous academic attitude, which is worth learning by all our colleagues. Pancreas of the First Affiliated Hospital of Nanjing Medical University The all-weather integrated pancreatic disease MDT diagnosis and treatment model established by the center not only provides patients with one-stop world-class pancreatic disease diagnosis and treatment services including surgery, endoscopy, drugs and other diagnosis and treatment methods, but also integrates pancreatic surgery, oncology, pancreas Specialists such as endoscopy, surgical infection and nutrition are united in real time, so that each colleague can have a more comprehensive professional view, so as to capture and solve key scientific problems in medical and scientific work, and further improve the Pancreatic Center. The continuous development of quality has laid a solid foundation and injected a strong impetus.”



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