Abstract

OBJECTIVE:To identify potential risk factors associated withpancreatic infection in severe acute pancreatisis (SAP) patients, thusproviding evidence for clinical prediction and treatment.

METHODS:A total of 42 patients with SAP collected in ourhospital from January 2013 to July 2014 were divided into two groups accordingto the presence or absence of pancreatic infection and retrospectivelyanalyzed. Clinical characteristics and laboratory examine results of the twogroups including age, sex, APACHE II score, serum amylase, serum calcium, bloodglucose, ALT, AST, hyoxemia, serum albumin, serum creatinine and blood ureanitrogen were investigated for their relevance to pancreatic infection.

RESULTS:The overall occurrence of secondary pancreaticinfection of the 42 patients was 52.38%. A significantly positive correlationwas revealed between the incidence rate of the secondary pancreatic infectionand the factors including hyoxemia, blood creatinine and urea nitrogen in SAPpatients (P < 0.05 or P < 0.01). Meanwhile, the level of serum albuminwas negatively correlated with the rate of secondary infection in SAP patients(P < 0.01). The rest factors showed no significant correlation (P >0.05).

CONCLUSION:Hyoxemia, blood creatinine and urea nitrogen arepotential factors leading to pancreatic infection in SAP patients, while anincrease of serum albumin may reduce the incidence of infection.